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Please use this identifier to cite or link to this item: http://hdl.handle.net/2237/26998

Title: Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
Authors: Ohtsuka, Hokuto
Takinami, Masahiro
Shimasaki, Takafumi
Hibi, Takahide
Murakami, Hiroshi
Aiba, Hirofumi
Issue Date: Jul-2017
Publisher: Wiley
Citation: Molecular Microbiology. v.105, n.1, 2017, p.84-97
Abstract: Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1^+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.
URI: http://doi.org/10.1111/mmi.13686
http://hdl.handle.net/2237/26998
ISSN: 0950-382X
Rights: "This is the peer reviewed version of the following article: [H.Ohtsuka, M.Takinami, T.Shimasaki,T.Hibi,H.Murakami,and H.Aiba,Molecular Microbiology.v.105,n.1, 2017,p.84-97]which has been published in final form at [http://doi.org/10.1111/mmi.13686]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Appears in Collections:1.学術雑誌(創薬)

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